Injections
Injectable testosterone (usually cypionate) is the most common and typically most cost-effective route. It's given weekly or twice-weekly, self-administered, and provides stable levels. The main downside is the needle — though many men adjust quickly. Providers like DudeMeds and PeterMD center on injections.
Cream and gel
Topical testosterone is applied to the skin daily — needle-free and steady, with a microdosing approach some men prefer. The trade-offs: it must be allowed to dry and there's a risk of transferring it to others through skin contact. Male Excel is known for its daily microdosing cream.
Top-Rated Providers
Telehealth testosterone support for men — including oral protocol options — with at-home testing
Recognizable men's telehealth brand — testosterone replacement therapy, 100% online
Physician-founded online TRT — injectable testosterone and enclomiphene, with at-home labsOral options
Modern oral testosterone (such as testosterone undecanoate) avoids needles entirely and is taken as a capsule. It's newer, tends to cost more, and requires taking it with food as directed. It's a good fit for men who want to avoid both needles and skin transfer.
Which should you choose?
There's no single best route — it depends on your preferences, budget and a clinician's assessment. Injections win on cost and stability; cream and oral win on convenience and being needle-free. Some providers offer all three, so you can switch. Compare them on our best TRT providers page. This article is general information, not medical advice.