ED shares its causes with the major chronic diseases of middle age. The NIDDK lists diabetes, heart and blood vessel disease, high blood pressure, chronic kidney disease, prostate cancer treatment, certain medicines, psychological factors, smoking, excess alcohol, excess weight and inactivity among them. Source: NIDDK, symptoms and causes of ED, checked November 2, 2026. The table below gives the numbers behind the main ones.
| Risk factor | Figure | Measure | Population and design | Source |
| Diabetes | 52.5% have ED; odds 3.62 times higher than healthy controls | Pooled prevalence; odds ratio (95% CI 2.53-5.16) | 145 studies, 88,577 men | Kouidrat et al., Diabetic Medicine, 2017 |
| Diabetes | 65.8% (95% CI 58.3-73.3) | Pooled prevalence | Umbrella review of 7 meta-analyses, 108,030 men | Kitaw et al., BMC Public Health, 2024 |
| Diabetes | 38.6% (age-adjusted); 51.3% (crude) | Prevalence | US men in NHANES 2001-2002 | Selvin et al., 2007 |
| High blood pressure | Odds 1.84 times higher (95% CI 1.58-2.14) | Pooled odds ratio | 18 cross-sectional studies, about 41,900 men | Wang et al., International Journal of Impotence Research, 2018 |
| Treated high blood pressure | 27.7% (age-adjusted) | Prevalence | US men in NHANES 2001-2002 | Selvin et al., 2007 |
| Obesity | Relative risk 1.9 (95% CI 1.6-2.2) | Risk of new ED over 14 years versus ideal weight | 22,086 US health professionals aged 40-75 | Bacon et al., Journal of Urology, 2006 |
| Current smoking | Odds 1.51 times higher (95% CI 1.34-1.71); former smokers 1.29 | Pooled odds ratio, prospective cohorts | 8 studies, 28,586 participants | Cao et al., PLoS ONE, 2013 |
| Smoking amount | Odds 1.14 higher per 10 cigarettes a day; 1.15 per 10 years of smoking | Dose-response odds ratio | 10 studies, 50,360 participants | dose-response meta-analysis, Journal of Sexual Medicine, 2014 |
| Physical inactivity | Relative risk 0.7 for the most active versus least active | Risk of new ED | 22,086 US health professionals | Bacon et al., 2006 |
| Depression | Depression raises odds of ED 1.39 times; ED raises odds of depression 2.92 times | Pooled odds ratios, as reported | Meta-analysis of observational studies | Liu et al., Journal of Sexual Medicine, 2018 |
| BPH and urinary symptoms | Men with ED 1.33 to 6.24 times more likely to have BPH | Range across studies | Global review | Kessler et al., 2019 |
| Cardiovascular disease, hypertension, diabetes, medications | Each independently linked to higher odds after age adjustment | Adjusted association | Massachusetts men aged 40-70 | Feldman et al., 1994 |
Sources as linked in the table, checked November 2, 2026.
How to read the risk numbers
An odds ratio or relative risk of 1.5 means the risk is about 50% higher than in the comparison group, not that 50% of men are affected. A man's absolute risk depends on his starting point: a 50% increase on a low base is a small number of extra cases. All of these figures come from observational studies, so they show association, not proof that the factor causes ED, although for diabetes, smoking and vascular disease the biological mechanism is well understood.
High blood pressure
The 2018 meta-analysis pooled 18 cross-sectional studies with about 41,900 participants and about 10,150 men with ED, and found high blood pressure associated with 1.84 times the odds of ED. The authors called for better prospective studies. Part of the link may run through the medicines: the NIDDK lists blood-pressure drugs among the medicines that can cause or worsen ED, which is a reason to raise it with the prescriber, never a reason to stop treatment. Sources: Wang et al., 2018; NIDDK, checked November 2, 2026. Our guide to ED pills and blood pressure medication covers the overlap.
Obesity and inactivity
Beyond the cohort figures above, there is trial evidence that weight loss helps. In a 2004 randomised trial in JAMA of 110 obese men aged 35 to 55 with ED, about a third of the men in the intensive lifestyle group (17 men) regained normal erectile function, against three men in the control group. Source: Esposito et al., JAMA, 2004 (PubMed), checked November 2, 2026. Our guide to GLP-1 drugs and ED covers what newer weight-loss drugs may mean for erections.
Smoking
The 2013 meta-analysis found current smokers had 1.51 times the odds of ED in prospective cohort studies, and former smokers 1.29 times, with no evidence of publication bias. The 2014 dose-response analysis found the odds rose with both the number of cigarettes a day and the number of years smoked, with no sign of a threshold. Sources: Cao et al., 2013; dose-response meta-analysis, 2014 (PubMed), checked November 2, 2026.
Depression
The link runs both ways. A 2018 meta-analysis in the Journal of Sexual Medicine reported that depression was associated with 1.39 times the odds of ED (95% CI 1.35-1.42) and ED with 2.92 times the odds of depression (95% CI 2.37-3.60). Heterogeneity between studies was very high, which the authors attributed to differences in design and in how both conditions were assessed. They recommended that men with ED be screened for depression and men with depression be asked about ED. Antidepressants are also on the NIDDK's list of medicines that can contribute. Sources: Liu et al., 2018 (PubMed); abstract summary, UroToday, checked November 2, 2026.
Urinary symptoms and BPH
The Multinational Survey of the Aging Male (MSAM-7) analysed 12,815 men aged 50 to 80 in the US and six European countries and concluded that the presence and severity of lower urinary tract symptoms were independent risk factors for sexual dysfunction in older men. The Kessler review put the association between ED and BPH at 1.33 to 6.24 times. Sources: Rosen et al., European Urology, 2003 (PubMed); Kessler et al., 2019, checked November 2, 2026.
Low testosterone
Low testosterone can reduce desire and contribute to ED, but it is one cause among several rather than the usual one, and in the Perth study of men aged 75 to 95 the authors judged it unlikely to be a major cause of sexual problems. Our guide to whether low testosterone can cause ED sets out when testing makes sense. Source: Hyde et al., 2012, checked November 2, 2026.