Semaglutide (the active ingredient in Ozempic and Wegovy) is one of the most effective GLP-1 medications for weight loss. Compare providers offering semaglutide treatment below.
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To find the best weight loss injections and programs, we compare leading GLP-1 providers on the factors that actually matter. Choosing the right weight loss provider involves more than selecting a medication — pricing, clinical support, treatment plans, eligibility requirements, and long-term value can vary significantly between providers. Not sure where to start? Try our provider matching quiz for a personalized recommendation.
To help simplify the decision, we reviewed leading weight loss programs and compared them based on medication access, affordability, provider support, customer experience, and overall value. Read our in-depth provider reviews for detailed breakdowns, or jump straight to a head-to-head like altRx vs embody.
Our goal is to help you identify the provider that best aligns with your health goals, budget, and treatment preferences.
Monthly costs can vary depending on the provider, medication prescribed, and level of support included in the program. Learn more about how to choose the right telehealth provider to understand what you should expect to pay.
Many providers offer all-inclusive plans that may include:
Some programs focus on affordability, while others provide more personalized care and additional clinical services.
Before starting GLP-1 treatment, it's important to understand a few key things. These medications require a prescription from a licensed clinician and aren't suitable for everyone. Some people may experience side effects, especially during the first few weeks as the body adjusts.
GLP-1s also tend to work best when combined with basic lifestyle habits like balanced nutrition and regular physical activity.
That's why choosing a provider that offers proper medical screening and ongoing follow-up support is essential for both safety and long-term success.
Before choosing a weight loss provider, it's important to evaluate several key factors. Our guide on what to expect your first month on medication can help you prepare:
Comparing providers side-by-side — like altRx vs Ro, altRx vs trimrx, or Embody vs Ro — can help you better understand the differences and make a more informed decision.
Many leading weight loss programs offer access to GLP-1 receptor agonist medications. Learn how GLP-1 medications actually work for a detailed breakdown. Common options include:
Medication availability may vary depending on your location, medical history, and provider policies. Prefer a non-injection option? See our guide to weight loss pills.
According to published clinical trial data, GLP-1 medications are the most effective prescription weight loss treatments currently available. Below is a summary of key statistics from major clinical trials.
| Medication | Avg. Weight Loss | Trial Duration | Compounded Price |
|---|---|---|---|
| Semaglutide (Wegovy) | ~15% of body weight | 68 weeks (STEP trials) | From $199/month |
| Tirzepatide (Zepbound) | Up to 22.5% of body weight | 72 weeks (SURMOUNT trials) | From $300/month |
| Liraglutide (Saxenda) | ~5–8% of body weight | 56 weeks | $1,300+/month (brand only) |
Source: Published results from STEP (semaglutide), SURMOUNT (tirzepatide), and SCALE (liraglutide) clinical trials. Individual results vary. Compounded pricing reflects typical telehealth provider rates as of August 2026.
Tirzepatide and semaglutide are the two most effective GLP-1 medications for weight loss. They work in similar ways but differ in average results, approvals, and coverage. Compare tirzepatide providers and semaglutide providers to see which fits your goals.
| Key Consideration | Tirzepatide | Semaglutide |
|---|---|---|
| Average Weight Loss in Trials | ~15.0%–20.9% average loss at 72 weeks (SURMOUNT) | ~14.9% mean loss at 68 weeks (STEP) |
| FDA Approval Status | FDA-approved for chronic weight management (Zepbound®); also approved for type 2 diabetes as Mounjaro® | FDA-approved for chronic weight management (Wegovy®); also approved for type 2 diabetes as Ozempic® |
| Dosing Schedule | Weekly injection | Weekly injection |
| Best For | Patients seeking greater average weight loss observed in clinical trials, when appropriate | Patients seeking an FDA-approved GLP-1 therapy with extensive long-term safety and outcomes data |
| Insurance Coverage | May not always be covered by insurance yet | Coverage varies; may be available on more formularies depending on insurer |
Both Wegovy and Ozempic use semaglutide, but the difference is in dosage and indication. Wegovy is tailored for weight loss, while Ozempic was developed for diabetes but is often prescribed off-label. See our Wegovy providers and Ozempic for weight loss guides for details.
| Key Consideration | Wegovy | Ozempic |
|---|---|---|
| Average Weight Loss in Trials | ~14.9% mean weight loss at 68 weeks in obesity-specific trials (STEP-1) | 5–10% weight loss observed in type 2 diabetes trials, depending on dose |
| FDA Approval Status | Yes, FDA-approved specifically for weight management | FDA-approved for type 2 diabetes; weight loss use is off-label |
| Dosing Schedule | Weekly injection | Weekly injection |
| Best For | Patients seeking an FDA-approved medication for long-term weight management | Patients with diabetes who may also benefit from weight loss |
| Insurance Coverage | Coverage varies; often limited for obesity medications | May have broader insurance coverage when prescribed for diabetes |
Source: STEP-1 (semaglutide) and SURMOUNT (tirzepatide) clinical trial data. Brand names Zepbound®, Mounjaro®, Wegovy®, and Ozempic® are trademarks of their respective manufacturers. Individual results vary; medications require a prescription from a licensed clinician.
Brand-name GLP-1 medications cost $900–$1,400 per month at retail price without insurance. Compounded versions of semaglutide and tirzepatide are available through licensed telehealth providers at significantly lower prices — typically $199–$500 per month including physician consultations, medication, and home delivery. Learn more in our complete cost guide.
Most patients notice reduced appetite within the first 1–2 weeks of starting GLP-1 medication. Visible weight loss typically begins around weeks 4–8. Clinical trial results show maximum weight loss at 68–72 weeks of treatment. Read our detailed semaglutide timeline.
Yes. Licensed telehealth providers can prescribe GLP-1 medications through fully online medical evaluations. The process typically takes 1–5 days from sign-up to medication delivery. All providers featured on our platform use licensed physicians for prescribing and include ongoing medical oversight. Read our guide to getting GLP-1 medication online.
Our rankings are based on a combination of factors including:
We continuously review and update our recommendations to help consumers compare leading weight loss solutions with confidence. Browse all weight loss articles for more research and guides.
